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DW-MRI of perfused and thermally controlled neuronal organotypic cultures

By U. Nevo, C. V. Stewart, E. D. Gireesh, D. Plenz and P. J. Basser


Signal attenuation in Diffusion Weighted MRI (DW-MRI) of the brain originates from multiple sources [1] that are being studied extensively, in order to quantify their relative contributions to the DW-MRI signal in health and disease. Recently it was also suggested that some of these mechanisms can be used to detect neuronal activity directly by DW-MRI [2]. However, sources of physiological ‘noise ’ such as bulk motion of the tissue, or flow of oxy/non-oxygenated blood, complicate the study of the physical origins of DW-MRI signal in-vivo, and the interpretations of signal changes. To address the question of biophysical origins of DW-MRI signal, while avoiding the use of fixed tissues or of in-vivo experiments, we use the experimental model of neuronal organotypic cultures. We mimic the physiological conditions by continuously perfusing the tissue, and maintaining it near physiological temperature

Year: 2011
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