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Considerations in Making Microarray Cross-Platform Correlations

By Manohar Kollegal, Sudeshna Adak and Timothy Sendera


Comparison and integration of expression data derived from diverse microarray platforms is challenging. Factors affecting cross-platform comparison of microarray data include the choice of normalization method used, annotation differences, presence of splice variants, RNA degradation and probe distance from 3 ’ end. A thorough evaluation of two commercial microarray platforms to determine an appropriate methodology for making cross-platform correlations is described here. 1

Year: 2011
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