Skip to main content
Article thumbnail
Location of Repository

Streptococcal Infections Associated with Asymptomatic Health-Care Workers 166 Notices to Readers

By Intravenous For Treatment Of, Hemolysis Associated and Human Albumin


plasma exchange (TPE), has existed in the United States. Because of this shortage, hospital pharmacists may prepare 5 % solution of human albumin by diluting 25% human albumin with 0.9 % NaCl or, when sodium load is a concern, 5 % dextrose. However, if sterile water alone is used as the diluent, the osmolarity (tonicity) of the albumin solution is reduced and may cause hemolysis in recipients. This report describes two of 10 episodes of hemolysis (one fatal) * among persons who received 25 % human albumin diluted with sterile water and emphasizes that sterile water alone should not be used to dilute albumin. Case 1 In January 1998, a 44-year-old patient in a Maine hospital underwent TPE with 5% human albumin prepared by diluting 25 % human albumin 1:5 with sterile water to treat cryoglobulinemia. After an infusion of 270 mL of the solution, the fluid in the plasma exchange device tubing became tinged red, and the procedure was stopped. The patient reported no symptoms; however, the patient’s hematocrit decreased within 24 hours from 36 % to 29 % (normal: 37%–48%) and 48 hours later, serum creatinin

Year: 2011
OAI identifier: oai:CiteSeerX.psu:
Provided by: CiteSeerX
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • (external link)
  • (external link)
  • Suggested articles

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.