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Systems Biology of Antigen Processing: From Structures to Mechanisms

By Alistair Bailey, Tim Elliott, Andrew Phillips and Jörn Werner


in the endoplasmic reticulum (ER) of cells. They are unstable in this empty ‘open ’ conformation. MHC Class I form a stable ‘closed ’ conformation when bound to an antigen peptide and can travel to the cell surface

Year: 2011
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