The segment minimization problem consists of representing an integer matrix as the sum of the fewest number of integer matrices each of which have the property that the non-zeroes in each row are consecutive. This has direct applications to an effective form of cancer treatment. Using several insights, we extend previous results to obtain constant-factor improvements in the approximation guarantees. We show that these improvements yield better performance by providing an experimental evaluation of all known approximation algorithms using both synthetic and real-world clinical data. Our algorithms are superior for 76 % of instances and we argue for their utility alongside the heuristic approaches used in practice
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