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Searching for a direct preparation of dihydropyrimidine-5carboxamides under Biginelli reaction conditions

By Irantzu Couto, Imanol Tellitu and Esther Domínguez


Dedicated to the memory of our colleague and friend Prof. Rafael Suau In this paper it is established a protocol leading to a series of dihydropyrimidine-5-carboxamides under Biginelli reaction conditions starting directly from 3-ketoamides as the 1,3-dicarbonyl component of the process. The best results have been found when chloroacetic acid is used as the catalyst under solvent free conditions

Topics: Multicomponent, Biginelli, dihydropyrimidines, heterocycles
Year: 2011
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