Histoplasmosis — is an Continued infection resulting from inhalation of spores from the dimorphic fungus Histoplasma capsulatum; the condition primarily affects the lungs. During August 1995, the Department for Health Services, Kentucky Cabinet for Human Resources (KDHS), and local public health officials investigated two unrelated outbreaks of acute histoplasmosis in eastern Kentucky. This report summarizes preliminary findings of the investigations of these outbreaks. Outbreak 1 On June 27, 1995, a crew of five workers began partial demolition of an abandoned city hall building in a community in Kentucky. At the time of demolition, a colony of bats had been observed in the vicinity of the building, and an approximately 2-foot– deep pile of debris covered with bat guano had accumulated in the building. During the demolition, none of the workers wore personal protective equipment (PPE) (i.e., respirators, eye protection, gloves, or protective clothing). Within 3 weeks, all five workers required treatment for acute respiratory illnesses, and three had been hospitalized. Lung biopsies were obtained from the three hospitalized patients; Giems
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