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MEDIA RELEASE IBN Develops Novel Injectable Hydrogel with Tunable Stiffness for Tissue Repair and Regeneration



institute, have developed the first injectable hydrogel system with variable stiffness that can control cell proliferation and differentiation in a two-dimensional (2D) and threedimensional (3D) cell culture environment. This unique hydrogel invention has important tissue engineering applications, especially in the treatment of neurological disorders, brain and muscle injuries 1. Human mesenchymal stem cells (hMSCs) are commonly used in cell therapies because they are easy to isolate and handle. hMSCs can differentiate into multiple cell types, such as osteoblasts (bone cells), neurons (nerve cells) and cardiac myocytes (heart muscle cells) via cell culture. The use of hydrogels as scaffolds for the cultivation of hMSCs is attractive because the former’s high water content matrix provides high permeability for oxygen, nutrients and other water-soluble metabolites. This quality makes them an excellent environment for cell growth and tissue regeneration. In addition, hydrogels can administer cells to the precise locations in the body for tissue repair and regeneration

Year: 2011
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