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Vol.1/Issue-4/Oct-Dec.2010 International Journal of Pharma and Bio Sciences SYNTHESIS, PRELIMINARY QSAR STUDY AND ANTIMICROBIAL ACTIVITY OF SOME NOVEL 2, 3-DISUBSTITUTED QUINAZOLINONE DERIVATIVES

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Abstract

A series of novel quinazolinone derivatives have been synthesized by the condensation of 2-substituted benzoxazine /6, 8-dibromo-2-substituted benzoxazine with p-amino containing compounds. Structures of the newly synthesized compounds have been established on the basis of their melting point, thin layer chromatography, IR and 1 H-NMR data. All the newly synthesized quinazolinone derivatives were evaluated for their anti-bacterial activity by disc diffusion method by measuring the zone of inhibition and the results were compared to standard

Topics: Quinazolinone derivatives, Anti-bacterial activity, p-amino compounds
Year: 2011
OAI identifier: oai:CiteSeerX.psu:10.1.1.185.1618
Provided by: CiteSeerX
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