Article thumbnail

Department of Cardiology, K.G. Hospital and Post Graduate Medical Institute,

By Palanisamy Pasupathi, G. Saravanan and J. Farook

Abstract

Oxidative stress plays an important role in the pathogenesis of some diseases such as lung cancer, chronic obstructive pulmonary disease, and atheroscleorosis. Smoking may enhance oxidative stress not only through the production of reactive oxygen radicals in smoke but also through weakening of the antioxidant defense systems. Cigarette smoke may promote atherogenesis by producing oxygen-derived free radicals that damage lipids. The present study was conducted to determine the effect of cigarette smoking on changes in lipid profile, lipid peroxidation and antioxidant status in cigarette smokers. The study population consisted of 200 male subjects divided into two groups; 100 smokers and age- and sex-matched non-smokers 100 subjects were selected. The mean systolic and diastolic blood pressure values were found to be significantly higher for smokers than for non-smokers. Biochemical parameters such as cardiac markers, lipid profile, apolipoproteins B and A1 (Apo B and A1), lipid peroxidation thiobarbituric acid reactive substances (TBARS) and antioxidants (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin A, vitamin C and vitamin E were measured. A highly significant increase in the levels of cardiac markers was found in smokers when compared with non-smokers. Enhanced lipid peroxidation with concomitant depletion of antioxidants was observed smokers as compared to non-smokers. The levels of serum total cholesterol, triglycerides, LDL and VLDL wer

Year: 2010
OAI identifier: oai:CiteSeerX.psu:10.1.1.180.3933
Provided by: CiteSeerX
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://citeseerx.ist.psu.edu/v... (external link)
  • http://www.jpsr.pharmainfo.in/... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.