NIEHS directives in Public Law 103-43. P.L. 103-43 directed NIEHS to develop and validate new test methods, and to establish criteria and processes for the validation and regulatory acceptance of toxicological testing methods. P. L. 106-545, the ICCVAM Authorization Act of 2000, established ICCVAM as a permanent committee. The Committee is composed of representatives from 15 Federal regulatory and research agencies and programs that generate, use, or provide information from toxicity test methods for risk assessment purposes. The Committee coordinates cross-agency issues relating to development, validation, acceptance, and national/international harmonization of toxicological test methods. The National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (Center) was established in 1998 to provide operational support for the ICCVAM, and to carry out committeerelated activities such as peer reviews and workshops for test methods of interest to Federal agencies. The Center and ICCVAM coordinate the scientific review of the validation status of proposed methods and provide recommendations regarding their usefulness to appropriate agencies. The NTP Center and ICCVAM seek to promote the validation and regulatory acceptance of toxicological test methods that will enhance agencies’ abilities to assess risks and make decisions, and that will refine, reduce, and replace animal use. The ultimat
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