Heuristic non parametric collateral missing value imputation : A step towards robust post-genomic knowledge discovery

Abstract

Microarrays are able to measure the patterns of expression of thousands of genes in a genometo give profiles that faciliate much faster analysis of biological process for diagnosis, prognosis and tailored drug discovery. Microarrays, however commonly have missing values, various algorithms have been proposed including Collateral Missing Value Estimation (CMVE), Bayesian Principal Component Analysis (BPCA), Least Square Impute (LSImpute). Local Least Square Impute (LLSImpute) and K-Nearest Neighbour (KNN)