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Drug Target Discovery Methods In Targeting Neurotropic Parasitic Amoebae

By Abdul Mannan Baig, Nuzair Waliani and Saiqa Karim

Abstract

Neurotropic parasitic amoebal infections have imposed an enormous challenge to chemotherapy in patients who fall victims to the infections caused by them. Conventional antibiotics that are given to treat these infections have a low patient compliance because of the serious adverse effects that are associated with their use. Additionally, the growing incidence of the development of drug resistance by the neurotropic parasites like Naegleria fowleri, Balamuthia mandrillaris, and Acanthamoeba spp has made the drug therapy more challenging. Recent studies have reported some cellular targets in the neurotropic parasitic Acanthamoeba that are used as receptors by human neurotransmitters like acetylcholine. This Viewpoint attempts to highlight the novel methodologies that use drug assays and structural modeling to uncover cellular targets of diverse groups of drugs and the safety issues of the drugs proposed for their use in brain infections caused by the neurotropic parasitic amoebae

Topics: 3D modeling, Acanthamoeba spp, Neurochemical receptors, brain-eating amoeba, drug safety, receptor discovery methods, structural homology
Publisher: eCommons@AKU
Year: 2017
OAI identifier: oai:ecommons.aku.edu:pakistan_fhs_mc_bbs-1700
Provided by: eCommons@AKU
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