Article thumbnail

Interactions of early-life stress with the genome and epigenome: from prenatal stress to psychiatric disorders

By Cristiana Cruceanu, Natalie Matosin and Elisabeth B Binder

Abstract

Adverse life events, especially early in life, have consistently been shown to strongly increase risk for psychiatric disorders like mood and anxiety disorders as well as psychoses. Both prenatal and postnatal stressors have been shown to have a long-lasting impact on adult psychopathology, and the type and timing of the stressors are important moderators of response severity. This is consistent with literature showing that during early development both prenatally and postnatally, the brain responds strongly to environmental cues while undergoing extensive dynamic changes. This review will highlight early life adversity and gene x early life adversity interactions that can have long-lasting effects on mental health. A main focus will be the role of epigenetics, especially DNA methylation, in mediating these lasting effects on the organism

Publisher: 'Sociological Research Online'
Year: 2017
OAI identifier: oai:ro.uow.edu.au:smhpapers1-1176
Provided by: Research Online
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://ro.uow.edu.au/smhpaper... (external link)

  • To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

    Suggested articles