We describe the clinical characteristics and outcomes of adults hospitalized with pneumonia during the pandemic (H1N1) 2009 outbreak. Patients admitted to a general hospital in San Luis Potosí, Mexico, from April 10 through May 11, 2009, suspected to have infl uenza virus–associated pneumonia were evaluated. We identifi ed 50 patients with suspected infl uenza pneumonia; the presence of infl uenza virus was confi rmed in 18: 11 with pandemic (H1N1) 2009 virus, 5 with unsubtypeable infl uenza A virus, 1 with seasonal infl uenza A virus (H3N2), and 1 in whom assay results for seasonal and pandemic (H1N1) viruses were positive. Eighteen patients were treated in the intensive care unit, and 10 died. During the pandemic (H1N1) 2009 outbreak, severe pneumonia developed in young adults who had no identifi able risk factors; early diagnosis and treatment of infl uenza virus infections may have a determinant role in outcome. novel influenza A virus, pandemic (H1N1) 2009 A virus, has been identified as the cause of an epidemic outbreak of respiratory illness throughout the world (1). Current information indicates that the pandemic (H1N1
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