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Formulation and Evalution of pH–Induced Povidone Iodine in Situ Gel for Oralthrush

By Jaya Raj Kumar. K, Ran. E and Srinivas. Gm

Abstract

Abstart: Candida species have become a major opportunistic pathogen causing recurrent oral thrush and oropharyngeal candidiasis topical delivery of antimicrobial agents is the most widely accepted approach aimed at prolonging active drug concentrations in the oral cavity. As most antifungal do not posses inherent ability to bind to the oral mucosa, This is best achieved through improved formulations, buccal adhesive gels are successfully used as drug delivery system consider their ability to prolong the drug release, the viscosity of the formulation was found to be in the fluid state at pH (5.8 to 6.0) before administration underwent rapid gelation upon pH 7.4. buccal in situ gels were formulated using different concentration of ion sensitive gellan gum (0.1 to 0.3),sodium alginate (0.1 to 0.5) and pH sensitive carbopol 934 (0.1 to 0.2) along with prolong release of PVP iodine (2%).formulation were evaluated for gelling capacity, viscosity, Gel strength, Bioadhesive force, spreadability drug content, FTIR and DSC

Topics: PVP-iodine, oral thrush, mucoadhesive gel, gellan gum, carbopol 934
Year: 2010
OAI identifier: oai:CiteSeerX.psu:10.1.1.169.4761
Provided by: CiteSeerX
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