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Experimental methods Supporting references

By Christopher K. Savile, Jacob M. Janey, Emily C. Mundorff, Jeffrey C. Moore, William R. Jarvis, Jeffrey C. Colbeck, Anke Krebber, Fred J. Fleitz, Jos Br, Paul N. Devine, Gjalt W. Huisman and Gregory J. HughesChristopher K. Savile, Jacob M. Janey, Emily C. Mundorff, Jeffrey C. Moore, Sarena Tam, William R. Jarvis, Jeffrey C. Colbeck, Anke Krebber, Fred J. Fleitz, Jos Br, Paul N. Devine, Gjalt W. Huisman and Gregory J. Hughes

Abstract

Supporting information Table of contents ATA-117 homology model development Library designs for establishing activity toward sitagliptin ketone Chronology of accumulated mutations and analysis derived from modeling Round 1a screening results for methyl ketone analog Round 1b and 2 screening results for pro-sitagliptin ketone Directed evolution of a process stable transaminase, rounds 3-11 Quantitation of catalyst improvement Development of process for conversion of pro-sitagliptin ketone to sitaglipti

Year: 2010
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