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GSI SCIENTIFIC REPORT 2008 MATERIALS-17 Gating of Single Synthetic Nanopores by DNA Molecular Switching *

By W. Guo, C. Trautmann and R. Neumann

Abstract

Switchable ion channels that are made of membrane proteins play crucial role in cellular circuits. Thereby synthetic nanofluidic channels attract great interest owing to the novel ion transport properties that are helpful for understanding the biological ion channels and for the promising applications on ultrasensitive molecular detection and separation [1]. Here we report a synthetic nanopore-DNA system where single solid-state nanopores are reversibly gated by switching DNA motors immobilized inside the nanopores. High- (on-state) and low- (off-state) conductance states are found within the nanopore-DNA system corresponding to the singlestranded and i-motif conformation of the DNA motors. The nanopores were fabricated by the ion-track technique. Chemical etching of the single-ion irradiate

Year: 2010
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