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MRP8 and MRP14, phagocyte-specific danger signals, are sensitive biomarkers of disease activity in cryopyrin-associated periodic syndromes

By Helmut Wittkowski, Jasmin B. Kuemmerle-Deschner, Judith Austermann, Dirk Holzinger, Raphaela Goldbach-Mansky, Katharina Gramlich, Peter Lohse, Thomas Jung, Johannes Roth, Susanne M. Benseler and Dirk Foell


To assess the sensitivity of the phagocyte-specific molecules myeloid-related protein (MRP) 8 and MRP14 (calprotectin) for monitoring disease activity during anti-interleukin (IL)-1 therapies in patients with cryopyrin-associated periodic syndromes (CAPS), including familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS) and chronic infantile neurological, cutaneous and articular (CINCA) syndrome

Topics: Medizin, ddc:610
Publisher: 'BMJ'
Year: 2011
DOI identifier: 10.1136/ard.2011.152496
OAI identifier:
Provided by: Open Access LMU
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