A novel non-parametric approach for correcting intensity non-uniformity in magnetic resonance (MR) data in an image volume is described. This model is based on smooth shifts in intensity within homogeneous materials and does not require radio frequency (RF) coil, tissue class models, or optimisation. The advantage of this computationally fast method is that it can be applied early in quantitative analysis while being independent of pulse sequence and insensitive to pathological processes. This algorithm has been tested on both real and simulated data. Application to tissue segmentation and functional MR imaging has shown a marked improvement in quantitative analysis.
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