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M. D. ANTOINE ET AL. Mass Spectral Analysis of Biological Agents Using the BioTOF Mass Spectrometer

By Miquel D. Antoine, Micah A. Carlson, Willie R. Drummond, Otis W. Doss Iii, C. Scott Hayek, Anshu Saksena and Jeffrey S. Lin


Aminiaturized MALDI-TOF mass spectrometer has been in development at APL for the last several years. Besides meeting the mechanical design challenges in taking a bench-top–sized instrument and shrinking it down for easy and rapid deployment with autonomous operation, sample collection and preparation methods have been developed to analyze, detect, and identify biological compounds in an aerosol. Validation of sample treatment strategies was accomplished with two independent processing schemes by quantifying several metrics and determining the effects of sample processing protocols on those metrics

Year: 2009
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