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Quantification of Lipoprotein Subclasses by Proton Nuclear Magnetic Resonance–Based Partial Least-Squares Regression Models

By Martin Petersen, Marianne Dyrby, Søren Toubro, Søren Balling Engelsen, Lars Nørgaard, Henrik Toft Pedersen and Jørn Dyerberg


Background: Cardiovascular disease risk can be estimated in part on the basis of the plasma lipoprotein profile. Analysis of lipoprotein subclasses improves the risk evaluation, but the traditional methods are very time-consuming. Novel, rapid, and productive methods are therefore needed. Methods: We obtained plasma samples from 103 fasting people and determined the plasma lipoprotein subclass profiles by an established ultracentrifugation-based method. Proton nuclear magnetic resonance (NMR) spectra were obtained from replicate samples on a 600 MHz NMR spectrometer. From the ultracentrifugationbased reference data and the NMR spectra, we developed partial least-squares (PLS) regression models to predict cholesterol and triglyceride (TG) concentration

Topics: Risk Factors
Year: 2004
OAI identifier: oai:CiteSeerX.psu:
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