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JCB Mini-Review The concept of self-organization in cellular architecture

By Tom Misteli


In vivo microscopy has recently revealed the dynamic nature of many cellular organelles. The dynamic properties of several cellular structures are consistent with a role for self-organization in their formation, maintenance, and function; therefore, self-organization might be a general principle in cellular organization. A central question in modern cell biology is how large, macroscopic cellular structures are formed and maintained. It is unknown what determines the different shapes and sizes of cellular organelles, why specific structures form in particular places, and how cellular architecture is affected by function and vice versa. Two fundamentally different mechanisms exist to generate macromolecular structures: self-assembly and self-organization. Whereas self-assembly involves the physical association o

Topics: The Jo
Year: 2009
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