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Diagnosis and Treatment of Alcoholic Liver Disease and Its Complications

By Luis S. Marsano, Christian Mendez, Daniell Hill, Shirish Barve, Ph. D and Craig J. Mcclain

Abstract

Alcoholic liver disease (ALD) is a serious and potentially fatal consequence of alcohol use. The diagnosis of ALD is based on drinking history, physical signs and symptoms, and laboratory tests. Treatment strategies for ALD include lifestyle changes to reduce alcohol consumption, cigarette smoking, and obesity; nutrition therapy; and pharmacological therapy. The diagnosis and management of the complications of ALD are important for alleviating the symptoms of the disease, improving quality of life, and decreasing mortality. KEY WORDS: alcoholic liver disorder; diagnosis; disease complication; treatment method; lifestyle; nutritional deficiency; vitamin therapy; drug therapy; propylthiouracil; colchicines; corticosterone; alternative medical treatment; S-adenosylmethionine; ascites; peritonitis; kidney disorder; esophageal varix; pentoxifylline; hepatorenal syndrome The liver is one of the largest and Cirrhosis and alcoholic hepatitis often of ALD, and ALD can be difficult to most complex organs in the body. coexist and cause substantial morbidity diagnose because patients frequently It performs multiple functions, and mortality. For example, studies from minimize or deny alcohol abuse. In including the production of proteins the Department of Veterans Affairs (VA) addition, there may be no evidence of and enzymes, detoxification, metabolic demonstrate that patients with both cir- ALD from the physical exam, and labfunctions, and the regulation of choles- rhosis and alcoholic hepatitis have a oratory abnormalities may not specifitero

Year: 2009
OAI identifier: oai:CiteSeerX.psu:10.1.1.135.402
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