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Brief Report Catechol O-Methyltransferase Polymorphism and Eye Tracking in Schizophrenia: A Preliminary Report

By Gunvant K. Thaker, Ikwunga Wonodi M. D, Matthew T. Avila, L. Elliot Hong, O. Colin Stine and Ph. D

Abstract

Objective: This study examined associations between functional polymorphism (Val108/158 Met) in the catechol O-methyltransferase (COMT) gene and eye tracking measures in schizophrenia. Method: Predictive pursuit and closed-loop gains of 62 patients with schizophrenia and 53 healthy comparison subjects with Val-Val, Val-Met, and Met-Met genotypes were compared. A functional polymorphism (Val 108/158 Met) in the catechol O-methyltransferase (COMT) gene is implicated in the etiology of schizophrenia (see Wonodi et al. [1] for review). The COMT gene affects the level of prefrontal dopamine, which modulates the way information is processed by prefrontal neurons during the performance of a number of important cognitive operations (2). The purpose of the current study was to examine the relationship between COMT polymorphism and smooth pursuit eye movements in subject

Year: 2009
OAI identifier: oai:CiteSeerX.psu:10.1.1.135.2771
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