Objective: This study examined associations between functional polymorphism (Val108/158 Met) in the catechol O-methyltransferase (COMT) gene and eye tracking measures in schizophrenia. Method: Predictive pursuit and closed-loop gains of 62 patients with schizophrenia and 53 healthy comparison subjects with Val-Val, Val-Met, and Met-Met genotypes were compared. A functional polymorphism (Val 108/158 Met) in the catechol O-methyltransferase (COMT) gene is implicated in the etiology of schizophrenia (see Wonodi et al.  for review). The COMT gene affects the level of prefrontal dopamine, which modulates the way information is processed by prefrontal neurons during the performance of a number of important cognitive operations (2). The purpose of the current study was to examine the relationship between COMT polymorphism and smooth pursuit eye movements in subject
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