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sound theoretical basis for any methodology before simplification can be carried out, and I note with regret the authors ' statement “we plan to do careful compartmental analysis in the future.⠀ It would seem more appropriate that before such a paper is written the careful compartmental analysis should be car ned out. There are very well established methods for measuring glomerular ifitration rate in the lit erature, and it is essential to compare a new and experimental method with a well known and ac cepted method rather than with estimates of expected renal function which can vary considerably from individual ment. to individual and from moment to m

Year: 2009
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