The directional selectivity of amacrine and ganglion cells was studied using conventional intracellular recording tech-niques and drug application in the superfused retina-eyecup preparation of the tiger salamander. Baclofen, a GABA, re-ceptor agonist, enhanced normal directional responses in some directionally selective third-order neurons. In about 30 % of the cells that were not normally directional, baclofen induced direction-selective responses. This effect was par-ticularly marked when 2-amino-4-phosphonobutyrate (APB) was used to isolate the OFF pathway. Comparisons of the effects of APB and baclofen on induced directional cells indicate that directional information in the ON and OFF chan-nels is often handled separately and frequently is not aligned. This tends to obscure the observation.of directionality as seen from the soma. Application of picrotoxin blocked bot
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