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An evolutionary trace method defines binding surfaces common to protein families

By Olivier Lichtarge, Henry R. Bourne and Fred E. Cohen

Abstract

1Departments of Cellular and X-ray or NMR structures of proteins are often derived without their Molecular Pharmacology and ligands, and even when the structure of a full complex is available, the area Medicine and of contact that is functionally and energetically significant may be a 2Department of Pharmaceutical Chemistry specialized subset of the geometric interface deduced from the spatial University of California proximity between ligands. Thus, even after a structure is solved, it San Francisco remains a major theoretical and experimental goal to localize protei

Topics: SH2 domains, SH3 domains, functional motifs, protein
Year: 1996
OAI identifier: oai:CiteSeerX.psu:10.1.1.134.8006
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