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CHARACTERISTICS OF NONDEPOLARIZING NEUROMUSCULAR BLOCK: (I) POST-JUNCTIONAL BLOCK BY ALPHA-BUNGAROTOXIN

By  and Chingmuh LeeDennis Chen, Ronald, L. Katz and Chingmuh Lee

Abstract

CLASSICALLY, a neuromuscular block characterized by lack of fasciculation, fade of the train-of-four 12 fade of tetanus, post-tetanic facilitation, and antagonism by the s de-curarizing agents, is called a "nondepolarizing " block. In view of the current understanding that d-tubocurarine (dTc) and pancuronium are pre-junctionally active, 3 one wonders whether these characteristics of "nondepolarizing " block may ^ be partially attributable to pre-junctional effects. We therefore searched for signs of a pure post-junctional non-depolarizing block. Alpha-bun garotoxin (a-BuTX), a polypeptide with a molecular weight of ap-, proximately 8,000, purified from snake venoms, has been known to produce a longlasting nondepolarizing neuromuscular block by "irreversible " binding to the postjunctional acetylcholine receptors 456 ' 7 or receptor sites sensitive to d-tubocurarine r (dTc) and acetylcholine (Ach). 8- 9 Because of its high affinity and specificity of binding with the Ach receptors, it has been used in tagging, solubilization, extraction, and purification of the Ach receptors from muscle and from the electric organ of eel, 8- 910 and in tagging of the Ach receptors in neurones. 11 When purified, it ha

Year: 2009
OAI identifier: oai:CiteSeerX.psu:10.1.1.134.5299
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