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Statistical challenges in functional genomics

By Paola Sebastiani and Marco Ramoni


On February 12, 2001 the Human Genome Project announced that it had assembled a draft physical map of the human genome- the genetic blueprint for a human being. Now the challenge is to annotate this map, by understanding the functions of genes and their interplay with proteins and the environment to create complex, dynamic living systems. This is the goal of functional genomics. Recent technological advances enable biomedical investigators to observe the genome of entire organisms in action by simultaneously measuring the level of activation of thousands of genes under the same experimental conditions. This technology, known as microarrays, provides today unparalleled discovery opportunities and it is reshaping biomedical sciences. One of the main aspects of this revolution is the introduction of heavily quantitative data-analytical methods in biomedical research. This paper reviews the foundations of this technolog

Topics: Bioinformatics, classification, clustering, differential analysis, gene expression, functional genomics, microarray
Year: 2003
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