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The Chromatin Structure of Centromeres from Fission Yeast: Differentiation of the Central Core that Correlates with Function

By Catherine Polizzi and Louise Clarke


Abstract. We have examined the chromatin structure of centromere regions from the fission yeast Schizosaccharomyces pombe. The large and complex centromere regions of the S. pombe chromosomes en-compass many kilobase pairs of DNA and contain several classes of tandemly repeated DNA sequences. The repeated sequences are further organized into a large inverted repeat flanking a central core, a con-served structural feature among all three centromeres in S. pombe. The nucleosomal configuration of the centromere regions is nonuniform and highly varied. Most of the centromere-specific repeated DNA se-quences are packaged into nucleosomes typical of bulk chromatin. However, the central core and core-associated repeated sequences from the centromer

Year: 2009
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