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Increased inwardly rectifying potassium currents in HEK-293 cells expressing murine transient receptor potential 4

By Zongming Zhang, Yufang Tang and Michael Xi Zhu

Abstract

Drosophila transient receptor potential (Trp) and its mammalian homologues are postulated to form capacitative Ca�+ entry or store-operated channels. Here we show that expression of murine Trp4 in HEK 293 cells also leads to an increase in inwardly rectifying K+ currents. No similar increase was found in cell lines expressing Trp1, Trp3 or Trp6. Consistent with typical characteristics of inward rectifiers, the K+ currents in Trp4-expressing cells were blocked by low millimolar concentrations of Cs+ and Ba�+, but not by 1.2 mM Ca�+, and were only slightly inhibited by 5 mM tetraethylammonium. Single channel recordings of excised inside-out patches revealed the presence of two con

Year: 2008
OAI identifier: oai:CiteSeerX.psu:10.1.1.134.1524
Provided by: CiteSeerX
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