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Article Abnormal Brain Activation During Inhibition and Error Detection in Medication-Naive Adolescents With ADHD

By Katya Rubia Ph. D, Anna B. Smith and Ph. DMichael J. Brammer and Ph. D

Abstract

Attention deficit hyperactivity disorder (ADHD) can be considered a generalized impulsivity disorder, with the traits of impulsivity manifesting at the motor, emotional, social, and attentional levels (1). It has been suggested that impulsiveness is best measured in tasks of inhibitory control, since one of the most consistent findings in ADHD neuropsychology is reduced performance on tasks of motor response inhibition such as the go/no-go (2, 3) and stop (3–5) tasks. Functional magnetic resonance imaging (fMRI) studies have shown that motor response inhibition is mediated— not exclusively, but most consistently—by prefrontal cortical brain areas and the basal ganglia. The go/no-go task has been the most widely used paradigm, but this task is confounded by comeasuring other cognitive processe

Year: 2008
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