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1-16 Protein Motifs Figure 1-49 Zinc finger motif A fragment



derived from a mouse gene regulatory protein is shown, with three zinc fingers bound spirally in the major groove of a DNA molecule. The inset shows the coordination of a zinc atom by characteristically spaced cysteine and histidine residues in a single zinc finger motif. The image is of Zif268. (PDB 1aay) Definitions convergent evolution: evolution of structures not related by ancestry to a common function that is reflected in a common functional motif. functional motif: sequence or structural motif that is always associated with a particular biochemical function. motif: characteristic sequence or structure that in the case of a structural motif may comprise a whol

Year: 2008
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