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Random Response Fluctuations Lead to Spurious

By Paired-pulse Facilitation, Jimok Kim and Bradley E. Alger


We studied paired-pulse depression (PPD) of GABA Aergic IPSCs under conditions of reduced transmitter release (caused by Cd 2 � , baclofen, or reduced stimulus intensity) with wholecell voltage clamp in CA1 pyramidal cells in vitro. The usedependent model of paired-pulse responsiveness holds that a decrease in the probability of neurotransmitter release during the first stimulus will cause predictable changes in the pairedpulse ratio (PPR, the amplitude of the second IPSC divided by that of the first). However, the applicability of the usedependent model to inhibitory synapses is controversial. Our results are inconsistent with this model, but are consistent with the hypothesis that random fluctuations in response size significantly influence PPR. PPR was sensitive to the extracellular stimulus intensity in all conditions. Changes in PPR were not correlated with changes in the first IPSC, but were correlate

Year: 2008
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