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Surface Modification by Plasma Polymerization and Application of Plasma Polymers as

By Der Johannes Gutenberg-universität Mainz, Zhihong Zhang, Dekan Prof and Dr. R. Zentel

Abstract

To my parents and daughter The work described in this thesis concerns the plasma polymers used for immobilization and adsorption of biomolecules. In particular, thin polymeric films bearing ether, anhydride, and amine functionalities were synthesis by plasma polymerization of these group containing monomers, i.e. di-(ethylene glycol) vinyl ether (EO2), maleic anhydride (MA), and allylamine (AA). Additionally, the characterization of these films, their surface properties, and solution behavior were investigated in detail. Self-assembled monolayer (SAM) of octadecanethiol coated Au substrates were functionalized with different groups by plasma polymerization. The adsorption of the proteins fibrinogen, bovine serum, and immunoglobulin to these surfaces could be measured in situ by SPR spectroscopy. The results showed that protein adsorption was affected significantly by the different surface functional groups, and the polymerization conditions, as well as the thickness. Among three plasma polymer films, the affinity of proteins on PEO2 and PPAA is higher than that on PMA. The DNA immobilizatio

Year: 2003
OAI identifier: oai:CiteSeerX.psu:10.1.1.124.2968
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