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Graded Positional Information Interpretation for Both Fate and Guidance

By Miriam Osterfield, Marc W Kirschner and John G Flanagan

Abstract

AbstractRecent evidence indicates that gradients of the same extracellular molecules can act as both morphogens, specifying cell differentiation, and guidance cues, directing axon movement. We discuss how cells may use common mechanisms to convert graded information into discrete responses; and how extracellular signals provide coordinate systems that can be linked to highly diverse cellular outputs

Publisher: Cell Press.
Year: 2003
DOI identifier: 10.1016/S0092-8674(03)00359-3
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