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Homology Modelling of the Structure of Human m3 Muscarinic Acetylcholine Receptor.

By Borroto-escuela D. O, Iarriccio L and Garriga P

Abstract

molecular modelling, sequence analysis. The m3 muscarinic acetylcholine receptor belongs to the family of rhodopsin-like Gprotein coupled receptors. This subtype of muscarinic receptors is of special interest because it is involved in a variety of physiological responses and several disorders, such as neurodegenerative diseases. Based on the X-ray structure of bovine rhodopsin and the sequence analysis of the muscarinic receptor family, a complete homology model of the human m3 receptor has been developed. Potential intramolecular interactions that are important for the stability of the protein fold have been identified. Other authors have experimentally studied, by site directed mutagenesis, the residues contributing to the binding site for the antagonist, N-methyl scopolamine, and the agonist, acetylcholine. Here we mapped these important residues. Experimental data combined with molecular modelling studies shed light on receptor-ligand interactions

Year: 2008
OAI identifier: oai:CiteSeerX.psu:10.1.1.121.5762
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