Article thumbnail

Multi-session statistics on beamformed MEG data

By Henry T. Luckhoo, Matthew J. Brookes and Mark W. Woolrich

Abstract

AbstractBeamforming has been widely adopted as a source reconstruction technique in the analysis of magnetoencephalography data. Most beamforming implementations incorporate a spatially-varying rescaling (which we term weights normalisation) to correct for the inherent depth bias in raw beamformer estimates. Here, we demonstrate that such rescaling can cause critical problems whenever analyses are performed over multiple sessions of separately beamformed data, for example when comparing effect sizes between different populations. Importantly, we show that the weights-normalised beamformer estimates of neural activity can even lead to a reversal in the inferred sign of the effect being measured. We instead recommend that no weights normalisation be carried out; any depth bias is instead accounted for in the calculation of multi-session (e.g. group) statistics. We demonstrate the severity of the weights normalisation confound with a 2-D simulation, and in real MEG data by performing a group statistical analysis to detect differences in alpha power in eyes-closed rest compared with continuous visual stimulation

Publisher: The Authors. Published by Elsevier Inc.
Year: 2014
DOI identifier: 10.1016/j.neuroimage.2013.12.026
OAI identifier:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://s3-eu-west-1.amazonaws... (external link)
  • https://s3.amazonaws.com/prod-... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.