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Onset of efficacy and residual speed of kill over one month of a topical dinotefuran-permethrin-pyriproxyfen combination (Vectra®3D) against the adult cat flea (Ctenocephalides felis felis) on dogs

By Marie Varloud and Josephus J. Fourie


AbstractThis study was designed to assess the onset of therapeutic and residual insecticidal efficacy of a topical ectoparasiticide (Vectra®3D, DPP) on dogs over one month against the cat flea, Ctenocephalides felis felis. Adult dogs (n=32, 11.0–18.7kg) were infested with 100 adult fleas on days −6, −2, 7, 14, 21 and 28. Based on flea retention, the dogs were allocated in two groups and were treated topically on day 0 with a control solution (CS) or DPP. Each group was divided in two subgroups in which live fleas were counted by combing the dogs 2 or 6h after treatment and at each re-infestation. The insecticidal efficacy was calculated using arithmetic and geometric means at each time point. The flea retention rate ranged from 64.0 to 86.5% in the CS group throughout the study. Based on arithmetic means, the therapeutic efficacy was 96.4% 6h post-treatment and residual efficacies ranged from 96.8 to 99.9% 2h after each re-infestation. The residual speed of killing effectiveness, >96% at 2h, persisted for one month after treatment. DPP administration was well tolerated. This study confirms that DPP starts killing fleas within 2h after treatment and reaches efficacy levels >95% at 6h. We have shown that DPP kills >96.8% of fleas for one month after treatment within 2h after infestation

Publisher: The Authors. Published by Elsevier B.V.
Year: 2015
DOI identifier: 10.1016/j.vetpar.2015.05.005
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