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Chromatin Modifications and Mast Cell Migration in UV-Induced Immunosuppression, an Epigenetic Piece of The Puzzle

By Remco van Doorn and Frank de Gruijl


The migration of dermal mast cells to skin-draining lymph nodes is a key step in UV-induced immunosuppression. Examining the effects of platelet-activating factor (PAF), a phospholipid mediator secreted by keratinocytes following UV exposure, on mast cells, Damiani et al. demonstrate that increased expression of CXCR4 is associated with increased histone acetylation at the promoter of this chemokine receptor gene

Publisher: The Society for Investigative Dermatology, Inc. Published by Elsevier Inc.
Year: 2015
DOI identifier: 10.1038/jid.2015.379
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