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Epithelial CaSR deficiency alters intestinal integrity and promotes proinflammatory immune responses

By Sam X. Cheng, Yaíma L. Lightfoot, Tao Yang, Mojgan Zadeh, Lieqi Tang, Bikash Sahay, Gary P. Wang, Jennifer L. Owen and Mansour Mohamadzadeh

Abstract

AbstractThe intestinal epithelium is equipped with sensing receptor mechanisms that interact with luminal microorganisms and nutrients to regulate barrier function and gut immune responses, thereby maintaining intestinal homeostasis. Herein, we clarify the role of the extracellular calcium-sensing receptor (CaSR) using intestinal epithelium-specific Casr−/− mice. Epithelial CaSR deficiency diminished intestinal barrier function, altered microbiota composition, and skewed immune responses towards proinflammatory. Consequently, Casr−/− mice were significantly more prone to chemically induced intestinal inflammation resulting in colitis. Accordingly, CaSR represents a potential therapeutic target for autoinflammatory disorders, including inflammatory bowel diseases

Publisher: Federation of European Biochemical Societies. Published by Elsevier B.V.
Year: 2014
DOI identifier: 10.1016/j.febslet.2014.05.007
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