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Mild heat shock induces cyclin D1 synthesis through multiple Ras signal pathways

By Song Iy Han, Su Young Oh, Won Je Jeon, Jung Mo Kim, Jun Hyuk Lee, Hae Young Chung, Yung Hyun Choi, Mi Ae Yoo, Han Do Kim and Ho Sung Kang


AbstractHyperthermia such as that occurring during fever may improve cell survival during infection, although its mechanism of action is largely unknown. Here we show that acute exposure to mild, but not severe, heat shock induces the synthesis of cyclin D1 that plays a critical role(s) in G1 progression of the cell cycle. This induction seemed to be regulated through multiple Ras signal pathways involving extracellular signal-regulated kinase, phosphatidylinositol 3-kinase, and Rac1/NADPH oxidase, all of which have well been documented to be responsible for growth factor-induced cyclin D1 expression. In a physiological sense, mild heat shock may regulate cell proliferation through inducing cyclin D1 along with growth factors

Publisher: Federation of European Biochemical Societies. Published by Elsevier B.V.
Year: 2002
DOI identifier: 10.1016/S0014-5793(02)02459-6
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