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Neurodegeneration: new clues on inclusions

By Peter T Lansbury and Kenneth S Kosik


AbstractThe rare neurological disorders frontotemporal dementia and British dementia have been linked to two mutant genes whose products constitute the fibrils that define the two disease pathologies. Two recent studies add to the mounting circumstantial case that protein fibrillization, inside (neurofibrillary tangles) or outside (amyloid plaques) of the neuron, may be pathogenic and suggest that either or both of these mechanisms could initiate Alzheimer’s disease

Publisher: Elsevier Science Ltd.
Year: 2000
DOI identifier: 10.1016/S1074-5521(00)00068-5
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