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Thymic Selection by a Single MHC/Peptide Ligand Autoreactive T Cells Are Low-Affinity Cells

By Dong-Sup Lee, Curie Ahn, Bettina Ernst, Jonathan Sprent and Charles D Surh

Abstract

AbstractIn H2-M− mice, the presence of a single peptide, CLIP, bound to MHC class II molecules generates a diverse repertoire of CD4+ cells. In these mice, typical self-peptides are not bound to class II molecules, with the result that a very high proportion of H2-M− CD4+ cells are responsive to the various peptides displayed on normal MHC-compatible APC. We show here, however, that such “self” reactivity is controlled by low-affinity CD4+ cells. These cells give spectacularly high proliferative responses but are virtually unreactive in certain other assays, e.g., skin graft rejection; responses to MHC alloantigens, by contrast, are intense in all assays. Possible explanations for why thymic selection directed to a single peptide curtails self specificity without affecting alloreactivity are discussed

Publisher: Cell Press.
Year: 1999
DOI identifier: 10.1016/S1074-7613(00)80009-6
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