Genetic Variants in Meiotic Program Initiation Pathway Genes Are Associated with Spermatogenic Impairment in a Han Chinese Population


) have been proposed to play key roles in spermatogenesis. genes, and evaluated their effects on spermatogenesis in our study population./ml). The control group consisted of 383 subjects with normal semen parameters, all of which had fathered at least one child without assisted reproductive technologies. genes were determined by TaqMan allelic discrimination assay in 719 idiopathic infertile men and 383 healthy controls. = 0.006, 0.002 respective). Notably, larger sample size studies and in vivo or in vitro functional studies are needed to substantiate the biological roles of these variants.Our results provided epidemiological evidence supporting the involvement of genetic polymorphisms of the meiotic program initiation genes in modifying the risk of azoospermia and oligozoospermia in a Han-Chinese population

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Last time updated on 6/5/2019

This paper was published in Public Library of Science (PLOS).

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