10.1371/journal.pone.0013012

Trypanosomiasis-Induced Th17-Like Immune Responses in Carp

Abstract

In mammalian vertebrates, the cytokine interleukin (IL)-12 consists of a heterodimer between p35 and p40 subunits whereas interleukin-23 is formed by a heterodimer between p19 and p40 subunits. During an immune response, the balance between IL-12 and IL-23 can depend on the nature of the pathogen associated molecular pattern (PAMP) recognized by, for example TLR2, leading to a preferential production of IL-23. IL-23 production promotes a Th17-mediated immune response characterized by the production of IL-17A/F and several chemokines, important for neutrophil recruitment and activation. For the cold blooded vertebrate common carp, only the IL-12 subunits have been described so far. infection, along with an increased gene expression of metalloproteinase-9 and chemokines.This is the first study that provides evidence for a Th17-like immune response in fish in response to infection with a protozoan parasite

Similar works

Full text

thumbnail-image

Public Library of Science (PLOS)

Provided original full text link
Last time updated on 6/5/2019

This paper was published in Public Library of Science (PLOS).

Having an issue?

Is data on this page outdated, violates copyrights or anything else? Report the problem now and we will take corresponding actions after reviewing your request.