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Guanine nucleotides and Ca-dependent exocytosis Studies on two adrenal cell preparations

By D.E. Knight and P.F. Baker

Abstract

AbstractExposure of ‘leaky’ adrenal medullary cells to GTP-γ-S inhibits Ca-dependent exocytosis in bovine cells, but stimulates exocytosis in chicken cells. The inhibitory action on bovine cells persists in the presence of TPA suggesting that in this tissue an inhibitory GTP-binding protein may modulate the action of protein kinase C on exocytosis

Publisher: Published by Elsevier B.V.
Year: 1985
DOI identifier: 10.1016/0014-5793(85)81053-X
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