Article thumbnail

Hard Times for Oncogenic BRAF-Expressing Melanoma Cells

By Miles D. Houslay

Abstract

In this issue of Cancer Cell, Arozarena et al. describe that the oncogenic BRAF Val600Glu mutant, which occurs in about half of melanomas, downregulates the cGMP-hydrolysing phosphodiesterase PDE5A in melanoma cells through the ERK-MAPK cascade coupled to the POU-domain transcription factor BRN2, thereby increasing intracellular cGMP levels and promoting invasiveness

Publisher: Elsevier Inc.
Year: 2011
DOI identifier: 10.1016/j.ccr.2011.01.004
OAI identifier:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://s3-eu-west-1.amazonaws... (external link)
  • https://s3.amazonaws.com/prod-... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.