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Classification and Regression Tree and Spatial Analyses Reveal Geographic Heterogeneity in Genome Wide Linkage Study of Indian Visceral Leishmaniasis

By Fakiola Michaela, Mishra Anshuman, Rai Madhukar, Singh Shri Prakash, O'Leary Rebecca A., Ball Stephen, Francis Richard W., Firth Martin J., Radford Ben T., Miller E. Nancy, Sundar Shyam and Blackwell Jenefer M.

Abstract

Genome wide linkage studies (GWLS) have provided evidence for loci controlling visceral leishmaniasis on Chromosomes 1p22, 6q27, 22q12 in Sudan and 6q27, 9p21, 17q11-q21 in Brazil. Genome wide studies from the major focus of disease in India have not previously been reported. = 0.002) and 1.84 (P = 0.001), respectively.GWLS has identified novel loci that show geographical heterogeneity in their influence on susceptibility to VL in India

Publisher: Public Library of Science
Year: 2010
DOI identifier: 10.1371/journal.pone.0015807
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